Karen Friedman Agnifilo

Karen Friedman Agnifilo is an American attorney and legal commentator known for her work as a former senior prosecutor in the Manhattan District Attorney’s Office and as a criminal defense lawyer in private practice.

Karen Friedman Agnifilo is an American attorney and legal commentator. She served as a senior prosecutor in the Manhattan District Attorney's Office in New York City and later became a criminal defense lawyer in private practice. She is also a media analyst and podcast co-host, and has been involved in high-profile cases such as the Luigi Mangione case.

Early life and education

Karen Friedman Agnifilo is reported to have studied at the University of California, Los Angeles, and later earned a law degree from Georgetown University Law Center. Public sources identify her as an American attorney born in 1966.

Prosecutorial career

She spent much of her career in the Manhattan District Attorney's Office, eventually becoming Chief Assistant District Attorney. Sources also describe earlier senior roles in the trial division and sex crimes unit, and note her involvement in major prosecutions.

Private practice and media work

After leaving the district attorney's office in 2021, she entered private practice and is listed as of counsel at Agnifilo Intrater LLP. She has also worked as a media legal analyst and podcast co-host.

Notable cases

Media coverage in late 2024 and 2025 identified her as defence counsel for Luigi Mangione in the case arising from the killing of UnitedHealthcare CEO Brian Thompson. These reports also noted her husband Marc Agnifilo's involvement in other high-profile criminal defence work.